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Nature Research, Nature Genetics, 10(42), p. 906-909, 2010

DOI: 10.1038/ng.661

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Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

Journal article published in 2010 by Terri L. Young, Mingzhi Zhang, Gudmar Thorleifsson, G. Bragi Walters, G. Bragi Walters, Alex W. Hewitt, Hreinn Stefansson, Gisli Masson, Dennis S. C. Lam, Pancy O. S. Tam, Gudrun J. Gudmundsdottir, Agnar Helgason, Laura Southgate ORCID, Kathryn P. Burdon ORCID, Maria Soffia Gottfredsdottir and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[A], odds ratio (OR) = 1.36, P = 5.0 × 10-10). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.