Published in
Oxford University Press, European Heart Journal, 22(36), p. 1405-1414, 2015
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Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction
Journal article published in 2015 by
Dimitrios A. Stakos,
Konstantinos Kambas,
Theocharis Konstantinidis,
Ioannis Mitroulis,
Eirini Apostolidou,
Stella Arelaki,
Victoria Tsironidou,
Alexandra Giatromanolaki,
Panagiotis Skendros 
,
Stavros Konstantinides ,
Konstantinos Ritis
,
Stavros Konstantinides ,
Konstantinos Ritis
This paper is available in a repository.
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Abstract
Neutrophils are involved in the pathophysiology of infracted coronary arteries in STEMI via NET structures. Platelets, activated by thrombin, are required for NET formation, while the integrity of NET scaffold contributes to the functionality of NET-bound TF. The blockage of NET formation or local neutralization of NET-mediated TF signalling constitutes candidate therapeutic targets.