Dissemin is shutting down on January 1st, 2025

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Springer, Journal of Cell Communication and Signaling, 2(9), p. 151-158, 2015

DOI: 10.1007/s12079-015-0260-3

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IGFBP-2 and −5: important regulators of normal and neoplastic mammary gland physiology

Journal article published in 2015 by James Beattie, Yousef Hawsawi ORCID, Hanaa Alkharobi, Reem El-Gendy
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The insulin-like growth factor (IGF) axis plays an important role in mammary gland physiology. In addition, dysregulation of this molecular axis may have a causal role in the aetiology and development of breast cancer (BC). This report discusses the IGF axis in normal and neoplastic mammary gland with special reference to IGF binding proteins (IGFBPs) -2 and −5. We describe how these high affinity binders of IGF-1 and IGF-2 may regulate local actions of growth factors in an autocrine and/or paracrine manner and how they also have IGF-independent effects in mammary gland. We discuss clinical studies which investigate both the prognostic value of IGFBP-2 and −5 expression in BC and possible involvement of these genes in the development of resistance to adjuvant endocrine therapies.