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Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 5(106), p. 613-616, 2011

DOI: 10.1590/s0074-02762011000500014

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Sequence analysis of the 2009 pandemic influenza A H1N1 virus haemagglutinin gene from 2009-2010 Brazilian clinical samples

Journal article published in 2011 by João Leandro de Paula Ferreira, Cecília Luiza Simões dos Santos, Brígido,Luis Fernando de Macedo, Luis Fernando de Macedo Brígido, Maria Isabel de Oliveira, Terezinha Maria de Paiva, João Leandro de Paula Ferreira, Samanta Etel Treiger Borborema ORCID, Luis Fernando de Macedo Brígido, Maria Isabel de Oliveira, Terezinha Maria de Paiva, Cecília Luiza Simões dos Santos
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this paper, we analysed the haemagglutinin (HA) gene identified by polymerase chain reaction from 90 influenza A H1N1 virus strains that circulated in Brazil from April 2009-June 2010. A World Health Organization sequencing protocol allowed us to identify amino acid mutations in the HA protein at positions S220T (71%), D239G/N/S (20%), Y247H (4.5%), E252K (3.3%), M274V (2.2%), Q310H (26.7%) and E391K (12%). A fatal outcome was associated with the D239G mutation (p < 0.0001). Brazilian HA genetic diversity, in comparison to a reference strain from California, highlights the role of influenza virus surveillance for study of viral evolution, in addition to monitoring the spread of the virus worldwide.