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Wiley, Journal of Thrombosis and Haemostasis, 2(12), p. 261-272, 2014

DOI: 10.1111/jth.12470

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G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis.

Journal article published in 2014 by Nl L. Stevenson, B. Martin-Martin, J. Freeman, J. Kriston-Vizi, R. Ketteler ORCID, Df F. Cutler ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

G protein-coupled receptors (GP-CRs) are a major family of signaling molecules, central to the regulation of inflammatory responses. Their activation upon agonist binding is attenuated by GPCR kinases (GRKs), which desensitize the receptors through phosphorylation. G protein-coupled receptor kinase 2(GRK2) down-regulation in leukocytes has been closely linked to the progression of chronic inflammatory disorders such as rheumatoid arthritis and multiple sclerosis. Because leukocytes must interact with the endothelium to infiltrate inflamed tissues, we hypothesized that GRK2 down-regulation in endothelial cells would also be pro-inflammatory.