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American Association for the Advancement of Science, Science, 5603(299), p. 114-116, 2003

DOI: 10.1126/science.1078062

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Regulation of Chromatin Remodeling by Inositol Polyphosphates

Journal article published in 2002 by David J. Steger, Elizabeth S. Haswell ORCID, Aimee L. Miller, Susan R. Wente, Erin K. O'Shea, Erin K. OòShea
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This paper is available in a repository.

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Abstract

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2 , which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate–dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.