Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Dunlop, Malcolm G.; Dobbins, Sara E.; Farrington, Susan Mary; Ma, Y. P.; Ooi, Li-Yin; Mg, Dunlop; Zgaga, Lina; Se, Dobbins; Thomas, Huw; Maher, Eamonn; Evans, Gareth; Walker, Lisa; Halliday, Dorothy; Cazier, Jean-Baptiste; Lucassen, Anneke; Palles, Claire; Paterson, Joan; Hodgson, Shirley; Homfray, Tessa; Side, Lucy; Izatt, Louise; Donaldson, Alan; Whiffin, Nicola; Sm, Farrington; Carvajal Carmona, Luis G.; Tomkins, Susan; Morrison, Patrick; Brewer, Carole; Henderson, Alex; Ma, Yusanne P.; Davidson, Rosemarie; Murday, Victoria; Tenesa, Albert; Cook, Jaqueline; Haites, Neva; Bishop, Timothy; Sheridan, Eamonn; Green, Andrew; Am, Jones; Prendergast, James; Marks, Christopher; Spain, Sarah; Carpenter, Sue; Broughton, Mary; Greenhalge, Lynn; Suri, Mohnish; Olver, Bianca; Kovacevia, D.; Penegar, Steven; Broderick, Peter; Lubbe, Steven; Chander, Ian; Edler, David; Starr, John M.; Lenander, Claes; Domingo, Enric; Ballereau, Stephane; Dalén, Johan; Hjern, Fredrik; Lloyd, Amy; Lundqvist, Nils; Lindforss, Ulrik; Jones, Angela M.; Påhlman, Lars; Vijayakrishnan, Jayaram; Aaltonen, Lauri A.; Smedh, Kennet; Smillie, Claire; Törnqvist, Anders; Holm, Jörn; Janson, Martin; Andersson, Magnus; Rudan, Igor; Ekelund, Susanne; Wilson, Charles; Mecklin, Jukka-Pekka; Olsson, Louise; Henrion, Marc; Theodoratou, Evropi; Jones, A. M.; MacDonald, Graham; Samuel, Leslie M.; Ahmad, Athar; Corrie, Philippa; Frampton, Matthew; White, Jeff; Jodrell, Duncan; Yosef, Hosney; Palmer, Cheryl; O'Hagan, Julie; Duggan, David J.; Smith, David; McDermott, Ray; Martin, Lynn; Walshe, Janice; Wilson, Richard; Cassidy, James; McDonald, Alec; Mohammed, Nazia; Breathnach, Oscar; Jenkins, Mark A.; Grogan, Liam; Grimes, Graeme; Thomas, Robert; Eatock, Martin; Henry, Paul; Houston, Russell; Deary, Ian; Gorman, Maggie; Johnston, Patrick; Kirac, Iva; Jb, Cazier; Geh, Ian; Danwata, Falalu; Hindley, Andrew; Susnerwala, Shabbir; Bradley, Chris; Conn, Andrew; Semple, Colin; Raine, Anne; Renkonen-Sinisalo, Laura; Twelves, Chris; Falk, Stephen; Hopkins, Kirstin; Wilson, Gregory; Tahir, Saad; Dhadda, Amandeep; Matsuda, Koichi; Maraveyas, Anthony; Ford, Victoria; Sgouros, Joseph; Nakamura, Yusuke; Teo, Mark; Ahmad, Rizvana; Cleator, Susan; Okada, Yukinori; Barclay, Ella; Creak, Antonia; Lowdell, Charles; Riddle, Philippa; Smith, Christopher G.; Benstead, Kim; Gallinger, Steven; Farrugia, David; Reed, Nicholas; Shepherd, Stephen; Levine, Edward; Cheadle, Jeremy P.; Conti, David; Mullamitha, Saifee; Saunders, Mark; Lg, Carvajal Carmona; Valle, Juan; Newcomb, Polly; Weaver, Andrew; Clark, Peter I.; Ly, Ooi; Haylock, Brain; Hopper, John; Iqbal, Mussawar I.; Myint, Arthur S.; Beesley, Sharon; Sevitt, Timothy; Nicoll, Jonathan; Schumacher, Fredrick; Daniel, Francis; Talbot, Toby; Butt, Mohammad; Casey, Graham; Hamid, Abdel; Mack, Paul; Roy, Raj; Easton, Douglas; Osborne, Richard; McKinna, Fiona; Alsab, Heidar; Shah, Mitul; Basu, Devyanee; Wilson, David; Murray, Phillip; Sizer, Bruce; Azam, Faisal A.; Pharoah, Paul; Neupane, Rekha; Waterston, Ashita; Lindblom, Annika; Glaholm, John; Blesing, Claire; Lowndes, Sarah; Medisetti, Aruna; Liu, Tao; Leslie, Martin; Maisey, Nicholas; Ross, Paul; Dunn, Grainne; Al-Salihi, Omar; Wasan, Harpreet S.; Tan, Li Tee; Dent, Jo; Consortium, Colorectal Tumour Gene Identification (CORGI); Hofmann, Uschi; Joffe, Johnathan K.; Sherwin, Elizabeth; Gaya, Andres; Soomal, Rabinder; Chakrabarti, Amitabha; Jm, Starr; Joseph, Shibu; West, Hannah; Kovacević, Dujo; Van der Voet, Johannes; Wadd, Nicholas J.; Anjarwalia, Salim; Hughes, Rob; Polychronis, Andrew; Wrigley, Jessica; Scarffe, John H.; Hill, Mark; James, Rodger D.; Shah, Riyaz; Summers, Jeffrey; Hartley, Andrew; Ford, H.; Carney, Desmond; Hall, Julia; McCaffrey, John; Bystricky, Brano; O'Reilly, Seamus; Gupta, Rajnish; Whillis, David; Al-Mishlab, Talib; Gidden, Fiona; O'Hara, Richard; Stewart, Jill; Ashford, Richard; La, Aaltonen; Glynne-Jones, Robert; Harrison, Mark; Mawdsley, Suzannah; Barlow, Hilary; Tighe, Mary; Walther, Julie; Neal, Janet; Rees, Charlotte; Bridgewater, John; Karp, Stephen; McGovern, Ursula; Atherton, Philip J.; El-Deeb, Hany; Wise, Marcus; Yp, Ma; Jones, Amanda; Jp, Mecklin; Macmillan, Craig; Patel, Kinnari; Bessell, Eric Michael; Gaya, Andrew; Dickinson, Peter D.; Potter, Vanessa; Jephcott, Catherine; Wilkins, Margeret; McAdam, Karen; Muthuramalingam, Sethupathi; O'Callaghan, Anne; Melcher, Lucinda; Braconi, Chiara; Geh, Ju Ian; Hall, J.; Palmer, Dan; Narayana, Priya; Steven, Neil; Rudman, Sarah; Chakraborti, Prabir; Kelly, Kay; Macgregor, Carol; Freebairn, Alice; Gildersleve, James; Sharif, Sahid; Astras, George; Hickish, Tamas; Beech, Darren; Ellis, Richard; Kulkarni, Rajendra; Wright, Kathryn; Shankland, K.; Dj, Duggan; Begent, Richard; Mayer, Astrid; Meyer, Timothy; Strauss, Sandra; Raj, Sanjay; Chau, Ian; Hall, Viriginia; Cunningham, David; Birtle, Alison; Biswas, Ashoke; Cummins, Sebastian; Essapen, Sharadah; Middleton, Gary; Topham, Claire; Langley, Ruth; Webb, Andrew; Wilkins, Marie; Iveson, Timothy John; Askill, Colin; Wagstaff, John; Azzabi, Ashraf; Bateman, Adrian; Prejbisz, Jan; Ma, Jenkins; Tsang, David; Ali, Nasim; O'Neill, Paul; Cottrill, Christopher; Propper, David; Lofts, Fiona Jane; Kennedy, James; Anthoney, David A.; Cooper, Rachel; Crellin, Adrian; Melcher, Alan; Seymour, Matthew; Baughan, Christopher; Ford, Hugo; Alexander, Emma; Crown, John; Fennelly, David; Williams, Rachel; Adab, Fawzi; Giridharan, Selvaraj; Pedley, Ian; Bliss, Peter; Cogill, Geoffrey; Lo, Nangi; Toy, Elizabeth; Hochhauser, Daniel; Ledermann, Jonathan; Brewster, Alison; Maughan, Timothy; Mort, Diana; Mukherjee, Somnath; Dobrowsky, Werner; Maughan, Tim; Calvert, Paula; Leonard, Gregory; Moody, Anne Margeret; Goriah, Sonia; Clive, Sally; Dawson, Lesley; McLean, Catriona; Phillips, Hamish Andrew; Gopi, Kakumudi; Tomlinson, Marjorie; Clenton, Susan; Furniss, Debra; Hornbuckle, Joanne; Pledge, Simon; Group, Swedish Low-Risk Colorectal Cancer Study; Wadsley, Jonathan; Abbas, Mohammed; Marshall, Ernest; Harper-Wynne, Catherine; Barnes, Anne; Kumar, Satish; Vigneswaran, Vallipuram; Cg, Smith; Gollins, Simon; Genton, M.; Sparrow, Geoff; Bale, Catherine; Fuller, C.; Mullard, Anna; Stuart, Nicholas; Keane, Maccon; Maughen, T.; Adams, Richard; Madi, Ayman; Jp, Cheadle; Hodgkinson, Elizabeth; Rogers, Penny; Pope, Malcolm; Kaplan, Rick; Meade, Angela; Coin, Collaborative Group; Parmar, Mahesh; Kenny, Sarah; Fisher, David; Harper, Lynda; Mitchell, Jena; Nichols, Laura; Sydes, Benjamin; Clement, Louise; Kay, Edward; Courtney, Cheryl; Gallagher, Madalena; Murphy, Claire; Thompson, Lindsay; Beall, Sarah; Dj, Kerr; Hassan, Sharma; Gracie, Richard; Griffiths, Gareth; Mason, Malcolm; Parker, Chris; Rudd, Robin; Midgley, Rachel; Johnson, Patrick; Whelan, Jeremy; Northover, John; Brown, Julia; Aapro, Matti; Kerr, David J.; Campbell, Harry; Ip, Tomlinson; Stout, Ronald; Tomlinson, Ian P.; Houlston, Richard S.; Rs, Houlston

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Claire Palles
Dunlop et al., 2012

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@article{Dunlop2012,
  abstract = {We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 ), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 ) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 ) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. © 2012 Nature America, Inc. All rights reserved.},
  author = {Dunlop, Malcolm G. and Dobbins, Sara E. and Farrington, Susan Mary and Ma, Y. P. and Ooi, Li-Yin and Mg, Dunlop and Zgaga, Lina and Se, Dobbins and Thomas, Huw and Maher, Eamonn and Evans, Gareth and Walker, Lisa and Halliday, Dorothy and Cazier, Jean-Baptiste and Lucassen, Anneke and Palles, Claire and Paterson, Joan and Hodgson, Shirley and Homfray, Tessa and Side, Lucy and Izatt, Louise and Donaldson, Alan and Whiffin, Nicola and Sm, Farrington and Carvajal Carmona, Luis G. and Tomkins, Susan and Morrison, Patrick and Brewer, Carole and Henderson, Alex and Ma, Yusanne P. and Davidson, Rosemarie and Murday, Victoria and Tenesa, Albert and Cook, Jaqueline and Haites, Neva and Bishop, Timothy and Sheridan, Eamonn and Green, Andrew and Am, Jones and Prendergast, James and Marks, Christopher and Spain, Sarah and Carpenter, Sue and Broughton, Mary and Greenhalge, Lynn and Suri, Mohnish and Olver, Bianca and Kovacevia, D. and Penegar, Steven and Broderick, Peter and Lubbe, Steven and Chander, Ian and Edler, David and Starr, John M. and Lenander, Claes and Domingo, Enric and Ballereau, Stephane and Dalén, Johan and Hjern, Fredrik and Lloyd, Amy and Lundqvist, Nils and Lindforss, Ulrik and Jones, Angela M. and Påhlman, Lars and Vijayakrishnan, Jayaram and Aaltonen, Lauri A. and Smedh, Kennet and Smillie, Claire and Törnqvist, Anders and Holm, Jörn and Janson, Martin and Andersson, Magnus and Rudan, Igor and Ekelund, Susanne and Wilson, Charles and Mecklin, Jukka-Pekka and Olsson, Louise and Henrion, Marc and Theodoratou, Evropi and Jones, A. M. and MacDonald, Graham and Samuel, Leslie M. and Ahmad, Athar and Corrie, Philippa and Frampton, Matthew and White, Jeff and Jodrell, Duncan and Yosef, Hosney and Palmer, Cheryl and O'Hagan, Julie and Duggan, David J. and Smith, David and McDermott, Ray and Martin, Lynn and Walshe, Janice and Wilson, Richard and Cassidy, James and McDonald, Alec and Mohammed, Nazia and Breathnach, Oscar and Jenkins, Mark A. and Grogan, Liam and Grimes, Graeme and Thomas, Robert and Eatock, Martin and Henry, Paul and Houston, Russell and Deary, Ian and Gorman, Maggie and Johnston, Patrick and Kirac, Iva and Jb, Cazier and Geh, Ian and Danwata, Falalu and Hindley, Andrew and Susnerwala, Shabbir and Bradley, Chris and Conn, Andrew and Semple, Colin and Raine, Anne and Renkonen-Sinisalo, Laura and Twelves, Chris and Falk, Stephen and Hopkins, Kirstin and Wilson, Gregory and Tahir, Saad and Dhadda, Amandeep and Matsuda, Koichi and Maraveyas, Anthony and Ford, Victoria and Sgouros, Joseph and Nakamura, Yusuke and Teo, Mark and Ahmad, Rizvana and Cleator, Susan and Okada, Yukinori and Barclay, Ella and Creak, Antonia and Lowdell, Charles and Riddle, Philippa and Smith, Christopher G. and Benstead, Kim and Gallinger, Steven and Farrugia, David and Reed, Nicholas and Shepherd, Stephen and Levine, Edward and Cheadle, Jeremy P. and Conti, David and Mullamitha, Saifee and Saunders, Mark and Lg, Carvajal Carmona and Valle, Juan and Newcomb, Polly and Weaver, Andrew and Clark, Peter I. and Ly, Ooi and Haylock, Brain and Hopper, John and Iqbal, Mussawar I. and Myint, Arthur S. and Beesley, Sharon and Sevitt, Timothy and Nicoll, Jonathan and Schumacher, Fredrick and Daniel, Francis and Talbot, Toby and Butt, Mohammad and Casey, Graham and Hamid, Abdel and Mack, Paul and Roy, Raj and Easton, Douglas and Osborne, Richard and McKinna, Fiona and Alsab, Heidar and Shah, Mitul and Basu, Devyanee and Wilson, David and Murray, Phillip and Sizer, Bruce and Azam, Faisal A. and Pharoah, Paul and Neupane, Rekha and Waterston, Ashita and Lindblom, Annika and Glaholm, John and Blesing, Claire and Lowndes, Sarah and Medisetti, Aruna and Liu, Tao and Leslie, Martin and Maisey, Nicholas and Ross, Paul and Dunn, Grainne and Al-Salihi, Omar and Wasan, Harpreet S. and Tan, Li Tee and Dent, Jo and Consortium, Colorectal Tumour Gene Identification (CORGI) and Hofmann, Uschi and Joffe, Johnathan K. and Sherwin, Elizabeth and Gaya, Andres and Soomal, Rabinder and Chakrabarti, Amitabha and Jm, Starr and Joseph, Shibu and West, Hannah and Kovacević, Dujo and Van der Voet, Johannes and Wadd, Nicholas J. and Anjarwalia, Salim and Hughes, Rob and Polychronis, Andrew and Wrigley, Jessica and Scarffe, John H. and Hill, Mark and James, Rodger D. and Shah, Riyaz and Summers, Jeffrey and Hartley, Andrew and Ford, H. and Carney, Desmond and Hall, Julia and McCaffrey, John and Bystricky, Brano and O'Reilly, Seamus and Gupta, Rajnish and Whillis, David and Al-Mishlab, Talib and Gidden, Fiona and O'Hara, Richard and Stewart, Jill and Ashford, Richard and La, Aaltonen and Glynne-Jones, Robert and Harrison, Mark and Mawdsley, Suzannah and Barlow, Hilary and Tighe, Mary and Walther, Julie and Neal, Janet and Rees, Charlotte and Bridgewater, John and Karp, Stephen and McGovern, Ursula and Atherton, Philip J. and El-Deeb, Hany and Wise, Marcus and Yp, Ma and Jones, Amanda and Jp, Mecklin and Macmillan, Craig and Patel, Kinnari and Bessell, Eric Michael and Gaya, Andrew and Dickinson, Peter D. and Potter, Vanessa and Jephcott, Catherine and Wilkins, Margeret and McAdam, Karen and Muthuramalingam, Sethupathi and O'Callaghan, Anne and Melcher, Lucinda and Braconi, Chiara and Geh, Ju Ian and Hall, J. and Palmer, Dan and Narayana, Priya and Steven, Neil and Rudman, Sarah and Chakraborti, Prabir and Kelly, Kay and Macgregor, Carol and Freebairn, Alice and Gildersleve, James and Sharif, Sahid and Astras, George and Hickish, Tamas and Beech, Darren and Ellis, Richard and Kulkarni, Rajendra and Wright, Kathryn and Shankland, K. and Dj, Duggan and Begent, Richard and Mayer, Astrid and Meyer, Timothy and Strauss, Sandra and Raj, Sanjay and Chau, Ian and Hall, Viriginia and Cunningham, David and Birtle, Alison and Biswas, Ashoke and Cummins, Sebastian and Essapen, Sharadah and Middleton, Gary and Topham, Claire and Langley, Ruth and Webb, Andrew and Wilkins, Marie and Iveson, Timothy John and Askill, Colin and Wagstaff, John and Azzabi, Ashraf and Bateman, Adrian and Prejbisz, Jan and Ma, Jenkins and Tsang, David and Ali, Nasim and O'Neill, Paul and Cottrill, Christopher and Propper, David and Lofts, Fiona Jane and Kennedy, James and Anthoney, David A. and Cooper, Rachel and Crellin, Adrian and Melcher, Alan and Seymour, Matthew and Baughan, Christopher and Ford, Hugo and Alexander, Emma and Crown, John and Fennelly, David and Williams, Rachel and Adab, Fawzi and Giridharan, Selvaraj and Pedley, Ian and Bliss, Peter and Cogill, Geoffrey and Lo, Nangi and Toy, Elizabeth and Hochhauser, Daniel and Ledermann, Jonathan and Brewster, Alison and Maughan, Timothy and Mort, Diana and Mukherjee, Somnath and Dobrowsky, Werner and Maughan, Tim and Calvert, Paula and Leonard, Gregory and Moody, Anne Margeret and Goriah, Sonia and Clive, Sally and Dawson, Lesley and McLean, Catriona and Phillips, Hamish Andrew and Gopi, Kakumudi and Tomlinson, Marjorie and Clenton, Susan and Furniss, Debra and Hornbuckle, Joanne and Pledge, Simon and Group, Swedish Low-Risk Colorectal Cancer Study and Wadsley, Jonathan and Abbas, Mohammed and Marshall, Ernest and Harper-Wynne, Catherine and Barnes, Anne and Kumar, Satish and Vigneswaran, Vallipuram and Cg, Smith and Gollins, Simon and Genton, M. and Sparrow, Geoff and Bale, Catherine and Fuller, C. and Mullard, Anna and Stuart, Nicholas and Keane, Maccon and Maughen, T. and Adams, Richard and Madi, Ayman and Jp, Cheadle and Hodgkinson, Elizabeth and Rogers, Penny and Pope, Malcolm and Kaplan, Rick and Meade, Angela and Coin, Collaborative Group and Parmar, Mahesh and Kenny, Sarah and Fisher, David and Harper, Lynda and Mitchell, Jena and Nichols, Laura and Sydes, Benjamin and Clement, Louise and Kay, Edward and Courtney, Cheryl and Gallagher, Madalena and Murphy, Claire and Thompson, Lindsay and Beall, Sarah and Dj, Kerr and Hassan, Sharma and Gracie, Richard and Griffiths, Gareth and Mason, Malcolm and Parker, Chris and Rudd, Robin and Midgley, Rachel and Johnson, Patrick and Whelan, Jeremy and Northover, John and Brown, Julia and Aapro, Matti and Kerr, David J. and Campbell, Harry and Ip, Tomlinson and Stout, Ronald and Tomlinson, Ian P. and Houlston, Richard S. and Rs, Houlston},
  doi = {10.1038/ng.2293},
  month = {may},
  title = {Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.},
  url = {http://www.nature.com/articles/ng.2293.pdf},
  year = {2012}
}

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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Journal article published in 2012 by Malcolm G. Dunlop, Sara E. Dobbins, Susan Mary Farrington, Y. P. Ma, Li-Yin Ooi, Dunlop Mg, Lina Zgaga, Dobbins Se, Huw Thomas, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Jean-Baptiste Cazier, Anneke Lucassen and other authors. Malcolm G. Dunlop, Sara E. Dobbins, Susan Mary Farrington, Y. P. Ma, Li-Yin Ooi, Dunlop Mg, Lina Zgaga, Dobbins Se, Huw Thomas, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Jean-Baptiste Cazier, Anneke Lucassen, Claire Palles

, Joan Paterson, Shirley Hodgson, Tessa Homfray, Lucy Side, Louise Izatt, Alan Donaldson, Nicola Whiffin

, Farrington Sm, Luis G. Carvajal Carmona, Susan Tomkins, Patrick Morrison, Carole Brewer, Alex Henderson, Yusanne P. Ma, Rosemarie Davidson, Victoria Murday, Albert Tenesa, Jaqueline Cook, Neva Haites, Timothy Bishop, Eamonn Sheridan, Andrew Green, Jones Am, James Prendergast, Christopher Marks, Sarah Spain

, Sue Carpenter, Mary Broughton, Lynn Greenhalge, Mohnish Suri, Bianca Olver, D. Kovacevia, Steven Penegar, Peter Broderick

, Steven Lubbe, Ian Chander, David Edler, John M. Starr, Claes Lenander, Enric Domingo, Stephane Ballereau, Johan Dalén, Fredrik Hjern, Amy Lloyd, Nils Lundqvist, Ulrik Lindforss, Angela M. Jones, Lars Påhlman, Jayaram Vijayakrishnan, Lauri A. Aaltonen, Kennet Smedh, Claire Smillie, Anders Törnqvist, Jörn Holm, Martin Janson, Magnus Andersson, Igor Rudan, Susanne Ekelund, Charles Wilson, Jukka-Pekka Mecklin, Louise Olsson, Marc Henrion

, Evropi Theodoratou, A. M. Jones, Graham MacDonald, Leslie M. Samuel, Athar Ahmad, Philippa Corrie, Matthew Frampton, Jeff White, Duncan Jodrell, Hosney Yosef, Cheryl Palmer, Julie O'Hagan, David J. Duggan, David Smith, Ray McDermott

, Lynn Martin, Janice Walshe, Richard Wilson, James Cassidy, Alec McDonald, Nazia Mohammed, Oscar Breathnach, Mark A. Jenkins, Liam Grogan, Graeme Grimes, Robert Thomas, Martin Eatock, Paul Henry, Russell Houston, Ian Deary, Maggie Gorman, Patrick Johnston, Iva Kirac, Cazier Jb, Ian Geh, Falalu Danwata, Andrew Hindley, Shabbir Susnerwala, Chris Bradley, Andrew Conn, Colin Semple, Anne Raine, Laura Renkonen-Sinisalo, Chris Twelves, Stephen Falk, Kirstin Hopkins, Gregory Wilson, Saad Tahir, Amandeep Dhadda, Koichi Matsuda

, Anthony Maraveyas, Victoria Ford, Joseph Sgouros, Yusuke Nakamura, Mark Teo, Rizvana Ahmad, Susan Cleator, Yukinori Okada, Ella Barclay, Antonia Creak, Charles Lowdell, Philippa Riddle, Christopher G. Smith, Kim Benstead, Steven Gallinger, David Farrugia, Nicholas Reed, Stephen Shepherd, Edward Levine, Jeremy P. Cheadle, David Conti, Saifee Mullamitha, Mark Saunders, Carvajal Carmona Lg, Juan Valle, Polly Newcomb, Andrew Weaver, Peter I. Clark, Ooi Ly, Brain Haylock, John Hopper, Mussawar I. Iqbal, Arthur S. Myint, Sharon Beesley, Timothy Sevitt, Jonathan Nicoll, Fredrick Schumacher, Francis Daniel, Toby Talbot, Mohammad Butt, Graham Casey, Abdel Hamid, Paul Mack, Raj Roy, Douglas Easton, Richard Osborne, Fiona McKinna, Heidar Alsab, Mitul Shah, Devyanee Basu, David Wilson, Phillip Murray, Bruce Sizer, Faisal A. Azam, Paul Pharoah, Rekha Neupane, Ashita Waterston, Annika Lindblom, John Glaholm, Claire Blesing, Sarah Lowndes, Aruna Medisetti, Tao Liu, Martin Leslie, Nicholas Maisey, Paul Ross, Grainne Dunn, Omar Al-Salihi, Harpreet S. Wasan, Li Tee Tan, Jo Dent, Colorectal Tumour Gene Identification (CORGI) Consortium, Uschi Hofmann, Johnathan K. Joffe, Elizabeth Sherwin, Andres Gaya, Rabinder Soomal, Amitabha Chakrabarti, Starr Jm, Shibu Joseph, Hannah West, Dujo Kovacević, Johannes Van der Voet, Nicholas J. Wadd, Salim Anjarwalia, Rob Hughes, Andrew Polychronis, Jessica Wrigley, John H. Scarffe, Mark Hill, Rodger D. James, Riyaz Shah, Jeffrey Summers, Andrew Hartley, H. Ford, Desmond Carney, Julia Hall, John McCaffrey, Brano Bystricky, Seamus O'Reilly, Rajnish Gupta, David Whillis, Talib Al-Mishlab, Fiona Gidden, Richard O'Hara, Jill Stewart, Richard Ashford, Aaltonen La, Robert Glynne-Jones, Mark Harrison, Suzannah Mawdsley, Hilary Barlow, Mary Tighe, Julie Walther, Janet Neal, Charlotte Rees, John Bridgewater, Stephen Karp, Ursula McGovern, Philip J. Atherton, Hany El-Deeb, Marcus Wise, Ma Yp, Amanda Jones, Mecklin Jp, Craig Macmillan, Kinnari Patel, Eric Michael Bessell, Andrew Gaya, Peter D. Dickinson, Vanessa Potter, Catherine Jephcott, Margeret Wilkins, Karen McAdam, Sethupathi Muthuramalingam, Anne O'Callaghan, Lucinda Melcher, Chiara Braconi, Ju Ian Geh, J. Hall, Dan Palmer, Priya Narayana, Neil Steven, Sarah Rudman, Prabir Chakraborti, Kay Kelly, Carol Macgregor, Alice Freebairn, James Gildersleve, Sahid Sharif, George Astras, Tamas Hickish, Darren Beech, Richard Ellis, Rajendra Kulkarni, Kathryn Wright, K. Shankland, Duggan Dj, Richard Begent, Astrid Mayer, Timothy Meyer, Sandra Strauss, Sanjay Raj, Ian Chau, Viriginia Hall, David Cunningham, Alison Birtle, Ashoke Biswas, Sebastian Cummins, Sharadah Essapen, Gary Middleton, Claire Topham, Ruth Langley, Andrew Webb, Marie Wilkins, Timothy John Iveson, Colin Askill, John Wagstaff, Ashraf Azzabi, Adrian Bateman, Jan Prejbisz, Jenkins Ma, David Tsang, Nasim Ali, Paul O'Neill, Christopher Cottrill, David Propper, Fiona Jane Lofts, James Kennedy, David A. Anthoney, Rachel Cooper, Adrian Crellin, Alan Melcher, Matthew Seymour, Christopher Baughan, Hugo Ford, Emma Alexander, John Crown, David Fennelly, Rachel Williams, Fawzi Adab, Selvaraj Giridharan, Ian Pedley, Peter Bliss, Geoffrey Cogill, Nangi Lo, Elizabeth Toy, Daniel Hochhauser, Jonathan Ledermann, Alison Brewster, Timothy Maughan, Diana Mort, Somnath Mukherjee, Werner Dobrowsky, Tim Maughan, Paula Calvert, Gregory Leonard, Anne Margeret Moody, Sonia Goriah, Sally Clive, Lesley Dawson, Catriona McLean, Hamish Andrew Phillips, Kakumudi Gopi, Marjorie Tomlinson, Susan Clenton, Debra Furniss, Joanne Hornbuckle, Simon Pledge, Swedish Low-Risk Colorectal Cancer Study Group, Jonathan Wadsley, Mohammed Abbas, Ernest Marshall, Catherine Harper-Wynne, Anne Barnes, Satish Kumar, Vallipuram Vigneswaran, Smith Cg, Simon Gollins, M. Genton, Geoff Sparrow, Catherine Bale, C. Fuller, Anna Mullard, Nicholas Stuart, Maccon Keane, T. Maughen, Richard Adams

, Ayman Madi, Cheadle Jp, Elizabeth Hodgkinson, Penny Rogers, Malcolm Pope, Rick Kaplan, Angela Meade, Collaborative Group Coin, Mahesh Parmar, Sarah Kenny, David Fisher, Lynda Harper, Jena Mitchell, Laura Nichols, Benjamin Sydes, Louise Clement, Edward Kay, Cheryl Courtney, Madalena Gallagher, Claire Murphy, Lindsay Thompson, Sarah Beall, Kerr Dj, Sharma Hassan, Richard Gracie, Gareth Griffiths, Malcolm Mason, Chris Parker, Robin Rudd, Rachel Midgley, Patrick Johnson, Jeremy Whelan, John Northover, Julia Brown, Matti Aapro, David J. Kerr, Harry Campbell, Tomlinson Ip, Ronald Stout, Ian P. Tomlinson, Richard S. Houlston, Houlston Rs

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Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 ), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 ) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 ) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. © 2012 Nature America, Inc. All rights reserved.

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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Abstract