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Hindawi, BioMed Research International, (2013), p. 1-5, 2013

DOI: 10.1155/2013/542810

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Growth Induction and Low-Oxygen Apoptosis Inhibition of Human CD34+ Progenitors in Collagen Gels

Journal article published in 2013 by Daniele Avitabile, Katrin Salchert, Carsten Werner, Maurizio C. Capogrossi, Maurizio Pesce
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.