Dissemin is shutting down on January 1st, 2025

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Wiley, Annals of Human Genetics, 5(77), p. 416-425, 2013

DOI: 10.1111/ahg.12027

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Post genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study

Journal article published in 2013 by Logan Dumitrescu, Cara L. Carty, Nora Franceschini, Lucia A. Hindorff, Shelley A. Cole, Petra Bůžková, Jeff Haessler, Fredrick R. Schumacher, Barbara Cochran, Ralph V. Shohet, Charles B. Eaton ORCID, Brian E. Henderson, Iona Cheng, Lynne R. Wilkens, Robert J. Goodloe and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Numerous common genetic variants that influence plasma high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) distributions have been identified via genome-wide association studies (GWAS). However, whether or not these associations are age dependent has largely been overlooked. We conducted an association study and meta-analysis in more than 22,000 European Americans between 49 previously identified GWAS variants and the three lipid traits, stratified by age (males: