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American Chemical Society, Journal of the American Chemical Society, 38(135), p. 14102-14105, 2013

DOI: 10.1021/ja408465t

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Temperature-Activated Nucleic Acid Nanostructures

Journal article published in 2013 by Ke Zhang, Xiao Zhu ORCID, Fei Jia, Evelyn Auyeung, Chad A. Mirkin
This paper is available in a repository.
This paper is available in a repository.

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Abstract

DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (~30 °C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.