Published in

Elsevier, Journal of Clinical Virology, 3(60), p. 257-263

DOI: 10.1016/j.jcv.2014.04.009

Links

Tools

Export citation

Search in Google Scholar

Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence

Journal article published in 2014 by Francesca Carozzi ORCID, Laura De Marco, Anna Gillio-Tos, Annarosa Del Mistro, Salvatore Girlando, Lorena Baboci, Morena Trevisan, Elena Burroni, Stefano Grasso, Paolo Giorgi Rossi ORCID, Guglielmo Ronco
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Background: The prevalence of infections with human papillomavirus (HPV) specific genotypes differs by age and areas. Knowledge of these differences will help predicting how prophylactic HPV vaccination and screening program could best be integrated. Objectives: To investigate variations in the HPV distribution between areas and ages in Italy and the impact of vaccination on HPV prevalence. Study design: 37,367 women aged 25-60 years who attended cervical screening in eight different areas in Northern and Central Italy were tested for HPV infection with the high-risk hybrid capture (hr-HC2) assay. hr-HC2 positive samples were genotyped by an intensive integrated strategy. Results: hr-HPV types were detected in 79.1% of HC2 positive women. HPV16 was the most frequent type, followed by HPV31, HPV18 and HPV56. A statistically significant variability in HPV type distribution between centres (overall Y,,284df 195.86 p