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Elsevier, Cellular Immunology, 2(272), p. 117-123

DOI: 10.1016/j.cellimm.2011.11.002

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Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions

Journal article published in 2011 by Jeong-Su Do, Gilles Foucras ORCID, Nobuhiko Kamada, Austin F. Schenk, Michael Shaw, Gabriel Nuñez, William E. Paul, Booki Min
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This paper is available in a repository.

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Abstract

Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally investigated. In this study, we utilized a pharmacologic inhibitor that blocks T cell egress from the lymphoid tissues, antibiotics, and germ-free animals to examine the role of commensal and self antigens. The results suggest that T cell proliferation under lymphopenic conditions is a heterogeneous process triggered by both exogenous commensal and endogenous self antigens.