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Lippincott, Williams & Wilkins, AIDS, 18(24), p. 2883-2887, 2010

DOI: 10.1097/qad.0b013e32833fed27

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Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia

Journal article published in 2010 by Job Cj J. Calis, Michaël Boele van Hensbroek, Kamija S. Phiri ORCID, Raymond Jwm W. M. Vet, Rob J. de Haan, Francis Munthali Dip Med, Francis Munthali, Robert J. Kraaijenhagen, Paul Jm M. Hulshof, Malcolm E. Molyneux, Bernard J. Brabin, Michael Boele van Hensbroek, Imelda Bates ORCID
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Abstract

Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.