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Wiley, Proteomics, 16(10), p. 3035-3039, 2010

DOI: 10.1002/pmic.200900370

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MassSieve: Panning MS/MS peptide data for proteins

Journal article published in 2010 by Douglas J. Slotta, Melinda A. McFarland ORCID, Sanford P. Markey
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We present MassSieve, a Java-based platform for visualization and parsimony analysis of single and comparative LC-MS/MS database search engine results. The success of mass spectrometric peptide sequence assignment algorithms has led to the need for a tool to merge and evaluate the increasing data set sizes that result from LC-MS/MS-based shotgun proteomic experiments. MassSieve supports reports from multiple search engines with differing search characteristics, which can increase peptide sequence coverage and/or identify conflicting or ambiguous spectral assignments.