Published in
Springer Verlag, Psychopharmacology, 6(232), p. 1083-1093
DOI: 10.1007/s00213-014-3743-7
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Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats
Journal article published in 2014 by
Andrea Cippitelli,
Lydia O. Ayanwuyi,
Estelle Barbier,
Esi Domi,
Jose M. Lerma-Cabrera,
Francisca Carvajal,
Giulia Scuppa 
,
Hongwu Li,
Massimo Ubaldi ,
Markus Heilig,
Marisa Roberto,
Roberto Ciccocioppo
,
Hongwu Li,
Massimo Ubaldi ,
Markus Heilig,
Marisa Roberto,
Roberto Ciccocioppo
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Abstract
Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found.