Abstract Background This study examined the effect of holiday season on the anthropometric measures in Shariati hospital staff. Methods This study was conducted in 2014 on 66 subjects, aged 21–68 years. Weight, height, waist circumference (WC), hip circumference (HC), waist -to-hip ratio (WHR), waist-to- height ratio (WHtR) and physical activity were measured. Bioelectrical impedance analysis (BIA) method and the Tanita body composition analyzer were used to analyze body composition. Results In this study, 80.3% of subjects were female and 19.7% were male. The mean age of subjects was 39.5 (SD: 9.7) years (range: 21–68). The percentage of overweight and obesity in the study population were 40.9% and 12.1%, respectively. After the holiday, participants gained 0.58 kg of weight and 0.19 units of BMI) P