Public Library of Science, PLoS ONE, 9(8), p. e74220, 2013
DOI: 10.1371/journal.pone.0074220
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Tuberculosis infection, disease and mortality are all less common at high than low altitude and ascent to high altitude was historically recommended for treatment. The immunological and mycobacterial mechanisms underlying the association between altitude and tuberculosis are unclear. We studied the effects of altitude on mycobacteria and antimycobacterial immunity.