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American Chemical Society, Journal of the American Chemical Society, 5(132), p. 1731-1731, 2010

DOI: 10.1021/ja910087w

American Chemical Society, Journal of the American Chemical Society, 28(131), p. 9843-9848, 2009

DOI: 10.1021/ja903316z

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Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery.

Journal article published in 2009 by M. Antonia Herrero ORCID, Toma F. M. Herrero, M. Antonia Herrero, Francesca Maria Toma, Khuloud T. Al-Jamal ORCID, Kostas Kostarelos, Alberto Bianco, Tatiana Da Ros, Fouzia Bano, Loredana Casalis, Giacinto Scoles, Maurizio Prato
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A new series of dendron-functionalized multiwalled carbon nanotube (MWNT) derivatives, characterized by the presence of numerous positively charged tetraalkyl ammonium salts at the periphery of the dendron, has been synthesized. The positive charges on the MWNT surface, coupled with the unique ability of carbon nanotubes (CNTs) to penetrate cell membranes, make the new derivatives potentially ideal vectors for siRNA delivery. Using a fluorescently labeled, noncoding siRNA sequence, we demonstrate that cytoplasmic delivery of the nucleic acid is remarkably increased throughout the different dendron generations. The work reported here highlights the fact that dendron-functionalized CNTs can be rationally designed as efficient carriers of siRNA that can eventually lead to gene silencing. ; Times Cited: 69 Bano, Fouzia/F-2879-2012 0 72