The supramolecular complex by DDMC/PTX which paclitxel(PTX)as guest is included to DEAE-dextran-MMA copolymer(DDMC)as host formed a nano-particle of 50-300 nm size.It was very useful as DDS for anticancer because of a stable polymeric micelle in vivo.MDR(multi-drug resistance)of melanoma cells B16F10 to PTX has been clearly shown in survival maximal curve.However,DDMC/PTX complex showed a superior anti-cancer efficacy following the Michaelis-Menthene kinetic,which may promote to tublin polymerization by allosteric reaction like enzyme reaction.It was also confirmed that the DDMC/PTX complex shows a very superior anti-cancer activity to PTX alone in mouse skin.The MST(median survival time)of DDMC/PTX groups[328 hours(T/C,2.73)]was twice as long as PTX of 176hours(T/C,1.46)(p