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Oxford University Press (OUP), Inflammatory Bowel Diseases, 2(21), p. 251-256

DOI: 10.1097/mib.0000000000000265

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Characterization of Expression Quantitative Trait Loci in the Human Colon

Journal article published in 2015 by Tarjinder Singh, Adam P. Levine ORCID, Philip J. Smith, Andrew M. Smith, Anthony W. Segal, Jeffrey C. Barrett ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Many genetic risk loci have been identified for inflammatory bowel disease and colorectal cancer; however, identifying the causal genes for each association signal remains a challenge. Expression quantitative trait loci (eQTL) studies have identified common variants that induce differential gene expression and eQTLs can be cross-referenced with disease association signals for gene prioritization. However, the genetics of gene expression are highly tissue-specific, and further eQTL datasets from primary tissues are needed.