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Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

Journal article published in 2013 by Frederick W. Miller, Jiří Vencovský, Lisa G. Rider, Robert G. Cooper, Lucy R. Wedderburn, Ingrid E. Lundberg, Lauren M. Pachman, Katalin Danko, Ann M. Reed, Steven R. Ytterberg, Leonid Padyukov, Albert Selva-O'Callaghan, Paul H. Plotz, Timothy R. D. J. Radstake, Paul Scheet and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

OBJECTIVE: To identify new genetic associations with juvenile and adult dermatomyositis (DM). METHODS: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. RESULTS: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P