Published in

Cell Press, American Journal of Human Genetics, 3(84), p. 367-379, 2009

DOI: 10.1016/j.ajhg.2009.02.001

Links

Tools

Export citation

Search in Google Scholar

Genome-wide association study of smoking initiation and current smoking

Journal article published in 2009 by Jacqueline M. Vink, Jacqueline M. Vink1, August B. Smit, Eco J. C. de Geus, Patrick Sullivan, Gonneke Willemsen, Jouke-Jan Hottenga, Hottenga Jj, Johannes H. Smit, Witte J. Hoogendijk, Frans G. Zitman, Leena Peltonen, Jaakko Kaprio, Nancy L. Pedersen, Patrik K. Magnusson and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.