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Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Journal article published in 2009 by
David Meyre,
Jerome Delplanque,
Jc C. Chèvre,
Cecile Lecoeur,
Stephane Lobbens,
Sophie Gallina 
,
Emmanuelle Durand,
Vincent Vatin,
Franck Degraeve,
Christine Proenca,
Stefan Gaget,
Antje Körner,
Antje Korner,
Peter Kovacs,
Wieland Kiess
and other authors.
,
Emmanuelle Durand,
Vincent Vatin,
Franck Degraeve,
Christine Proenca,
Stefan Gaget,
Antje Körner,
Antje Korner,
Peter Kovacs,
Wieland Kiess
and other authors.
Abstract
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).