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Common variants at 30 loci contribute to polygenic dyslipidemia

Journal article published in 2008 by Paul I. deBakker, Sekar Kathiresan, Pi de Bakker, Cj Willer, Gm Peloso, Serkalem Demissie, Kiran Musunuru, Eric Ee Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka, Bf Voight, Lori Ll Bonnycastle, Au Jackson and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.