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Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
Journal article published in 2011 by
Marcus J. Rijken 
,
Machteld E. Boel,
Bruce Russell,
Mallika Imwong,
Mara L. Leimanis,
Aung Pyae Phyo,
Atis Muehlenbachs,
Niklas Lindegardh,
Rose McGready,
Laurent Rénia,
Georges Snounou,
Pratap Singhasivanon,
François Nosten
,
Machteld E. Boel,
Bruce Russell,
Mallika Imwong,
Mara L. Leimanis,
Aung Pyae Phyo,
Atis Muehlenbachs,
Niklas Lindegardh,
Rose McGready,
Laurent Rénia,
Georges Snounou,
Pratap Singhasivanon,
François Nosten
Abstract
Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.