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Springer Nature [academic journals on nature.com], Cell Death and Disease, 11(5), p. e1520-e1520, 2014

DOI: 10.1038/cddis.2014.491

Springer Nature [academic journals on nature.com], Cell Death and Disease, 8(5), p. e1399-e1399, 2014

DOI: 10.1038/cddis.2014.366

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The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation

Journal article published in 2014 by M. S. Rodriguez, I. Egaña, F. Lopitz-Otsoa ORCID, M. P. Lopez-Mato, A. Dorronroso, F. Aillet, A. Dorronsoro, S. Lobato-Gil, J. D. Sutherland, Rosa Barrio ORCID, C. Trigueros, V. Lang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractAccurate regulation of nuclear factor-κB (NF-κB) activity is crucial to prevent a variety of disorders including immune and inflammatory diseases. Active NF-κB promotes IκBα and A20 expression, important negative regulatory molecules that control the NF-κB response. In this study, using two-hybrid screening we identify the RING-type zinc-finger protein 114 (RNF114) as an A20-interacting factor. RNF114 interacts with A20 in T cells and modulates A20 ubiquitylation. RNF114 acts as negative regulator of NF-κB-dependent transcription, not only by stabilizing the A20 protein but also IκBα. Importantly, we demonstrate that in T cells, the effect of RNF114 is linked to the modulation of T-cell activation and apoptosis but is independent of cell cycle regulation. Altogether, our data indicate that RNF114 is a new partner of A2O involved in the regulation of NF-κB activity that contributes to the control of signaling pathways modulating T cell-mediated immune response.