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Royal Society of Chemistry, Chemical Science, 6(7), p. 3742-3750, 2016

DOI: 10.1039/c6sc00370b

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Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase

Journal article published in 2016 by Nevena Cekic, Julia E. Heinonen, Keith A. Stubbs, Christian Roth ORCID, Yuan He, Andrew J. Bennet, Ernest J. McEachern, Gideon J. Davies ORCID, David J. Vocadlo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

2′-Aminothiazoline inhibitors of human OGA are tight binding transition state mimics for which binding depends on inhibitor pKa.