Published in

BioMed Central, BMC Cancer, 1(15), 2015

DOI: 10.1186/s12885-015-1238-5

Links

Tools

Export citation

Search in Google Scholar

Circulating miR-200c and miR-141 and outcomes in patients with breast cancer

Journal article published in 2015 by Silvia Antolín, Lourdes Calvo ORCID, Moisés Blanco-Calvo, María Paz Santiago, María Paz Santiago, María José Lorenzo-Patiño, Mar Haz-Conde, Isabel Santamarina, Angélica Figueroa, Luis Miguel Antón-Aparicio, Manuel Valladares-Ayerbes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Research article ; [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 in the whole blood can identify breast cancer (BC), and could be developed into a prognostic signature. Methods. The expression of miR-200c and miR-141 were examined in bloods (57 stage I-IV BC patients and 20 age-matched controls) by quantitative reverse-transcription PCR. The associations of circulating microRNAs with clinic and pathological characteristics were analysed. Their effects on survival were analysed by the Kaplan-Meier method and Cox regressions. Results. MiR-200c was down regulated (P