This paper presents a comparative study of the adsorption activity of the grass meal of lady's mantle aerial part (Alchemilla vulgaris) and modern adsorption materials – activated carbon (carbolenum) and hydrolyzed lignin (polyphepane) towards model substances (markers of adsorption). The model substances were used to effectively simulate a group of toxic substances with different molar mass and degree of ionogenicity in the environment that simulates gastric and intestinal juices. It was shown that hydrolized lignin had the highest protein adsorption activity and activated carbon appeared the most active in sorbing toxicants with low molar mass. The grass meal of lady's mantle aerial parts (Alchemilla vulgaris) was able to moderately absorb both high-molar mass and low-molar mass substances at an average degree of dispersion of the raw material. It is supposed that it was mainly due to the high-porous structure of the material. This shows the versatility of the enterosorbent under development.