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Springer (part of Springer Nature), Journal of Clinical Immunology, 1(33), p. 210-219

DOI: 10.1007/s10875-012-9770-4

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Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Journal article published in 2012 by Angelica B. W. Boldt, Maria Iolanda N. Sanchez, Ewalda R. S. Stahlke, Rudi Steffensen, Steffen Thiel, Jens Christian Jensenius, Flávia Costa Prevedello, Marcelo Távora Mira ORCID, Jürgen F. J. Kun, Iara J. T. Messias-Reason ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility.