Dissemin is shutting down on January 1st, 2025

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EMBO Press, EMBO Reports, 4(1), p. 313-318, 2000

DOI: 10.1093/embo-reports/kvd075

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Chunnel vision

Journal article published in 2000 by Christian Andersen, Colin Hughes, Vassilis Koronakis ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The Escherichia coli TolC protein is central to toxin export and drug efflux across the inner and outer cell membranes and the intervening periplasmic space. The crystal structure has revealed that TolC assembles into a remarkable alpha-helical trans-periplasmic cylinder (tunnel) embedded in the outer membrane by a contiguous beta-barrel (channel), so providing a large duct open to the outside environment. The channel-tunnel structure is conserved in TolC homologues throughout Gram-negative bacteria, and it is envisaged that they are recruited and opened, through a common mechanism, by substrate-specific inner-membrane complexes.