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EMBO Press, EMBO Reports, 3(1), p. 260-265, 2000

DOI: 10.1093/embo-reports/kvd059

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BRCA1 can stimulate gene transcription by a unique mechanism

Journal article published in 2000 by Guy Nadeau, Nadia Boufaied, Annie Moisan, Karine M. Lemieux, Charmagne Cayanan, Alvaro N. A. Monteiro ORCID, Luc Gaudreau
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Most familial breast and ovarian cancers have been linked to mutations in the BRCA1 gene. BRCA1 has been shown to affect gene transcription but how it does so remains elusive. Here we show that BRCA1 can stimulate transcription without the requirement for a DNA-tethering function in mammalian and yeast cells. Furthermore, the BRCA1 C-terminal region can stimulate transcription of the p53-responsive promoter, MDM2. Unlike many enhancer-specific activators, non-tethered BRCA1 does not require a functional TATA element to stimulate transcription. Our results suggest that BRCA1 can enhance transcription by a function additional to recruiting the transcriptional machinery to a targeted gene.