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Elsevier, Journal of Thoracic Oncology, 7(10), p. 1067-1075, 2015

DOI: 10.1097/jto.0000000000000549

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Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I–III Non–Small-Cell Lung Cancer

Journal article published in 2015 by Dylan M. Glubb ORCID, Laia Paré-Brunet, Eloisa Jantus-Lewintre, Chen Jiang, Daniel Crona ORCID, Amy S. Etheridge, Osman Mirza, Wei Zhang, Eric L. Seiser, Witold Rzyman, Jacek Jassem, Todd Auman, Fred R. Hirsch, Kouros Owzar, Carlos Camps and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Acceso abierto en: http://dx.doi.org/10.1097/JTO.0000000000000549 ; Background: We propose that single-nucleotide polymorphisms (SNPs) in genes of the vascular endothelial growth factor pathway of angiogenesis will associate with survival in non-small-cell lung cancer (NSCLC) patients. Methods: Fifty-three SNPs in vascular endothelial growth factor-pathway genes were genotyped in 150 European stage I-III NSCLC patients and tested for associations with patient survival. Replication was performed in an independent cohort of 142 European stage I-III patients. Reporter gene assays were used to assess the effects of SNPs on transcriptional activity. Results: In the initial cohort, five SNPs associated (q