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Public Library of Science, PLoS ONE, 2(4), p. e4581, 2009

DOI: 10.1371/journal.pone.0004581

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A Novel Immunological Assay for Hepcidin Quantification in Human Serum

Journal article published in 2009 by Vasiliki Koliaraki, Martha Marinou, Theodoros P. Vassilakopoulos, Eustathios Vavourakis, Emmanuel Tsochatzis ORCID, Gerassimos A. Pangalis, George Papatheodoridis ORCID, Alexandra Stamoulakatou, Dorine W. Swinkels, George Papanikolaou, Avgi Mamalaki
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hepcidin is a 25-aminoacid cysteine-rich iron regulating peptide. Increased hepcidin concentrations lead to iron sequestration in macrophages, contributing to the pathogenesis of anaemia of chronic disease whereas decreased hepcidin is observed in iron deficiency and primary iron overload diseases such as hereditary hemochromatosis. Hepcidin quantification in human blood or urine may provide further insights for the pathogenesis of disorders of iron homeostasis and might prove a valuable tool for clinicians for the differential diagnosis of anaemia. This study describes a specific and non-operator demanding immunoassay for hepcidin quantification in human sera.