Published in
Public Library of Science, PLoS ONE, 3(8), p. e59248, 2013
DOI: 10.1371/journal.pone.0059248
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Therapeutic Efficacy of C-Kit-Targeted Radioimmunotherapy Using 90Y-Labeled Anti-C-Kit Antibodies in a Mouse Model of Small Cell Lung Cancer
Journal article published in 2013 by
Chisato Yoshida,
Atsushi B. Tsuji 
,
Hitomi Sudo,
Aya Sugyo,
Tatsuya Kikuchi,
Mitsuru Koizumi,
Yasushi Arano,
Tsuneo Saga
,
Hitomi Sudo,
Aya Sugyo,
Tatsuya Kikuchi,
Mitsuru Koizumi,
Yasushi Arano,
Tsuneo Saga
This paper is made freely available by the publisher.
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Abstract
Small cell lung cancer (SCLC) is an aggressive tumor and prognosis remains poor. Therefore, the development of more effective therapy is needed. We previously reported that high levels of an anti-c-kit antibody (12A8) accumulated in SCLC xenografts. In the present study, we evaluated the efficacy of two antibodies (12A8 and 67A2) for radioimmunotherapy (RIT) of an SCLC mouse model by labeling with the 90Y isotope.