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Elsevier, Structure, 9(21), p. 1479-1481, 2013

DOI: 10.1016/j.str.2013.08.011

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A New RING Tossed into an Old HAT

Journal article published in 2013 by Alison E. Ringel, Cynthia Wolberger ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. In the August issue of NSMB, Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme’s activity.