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Baishideng Publishing Group, World Journal of Gastroenterology, 2(14), p. 200, 2008

DOI: 10.3748/wjg.14.200

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Role of the JNK signal transduction pathway in inflammatory bowel disease

Journal article published in 2008 by Farzana Rashid, Praveen K. Roy, Jack Bragg, Division of Gastroenterology and Hepatology, Jamal A. Ibdah ORCID, University of Missouri School of Medicine, United States, Columbia, Missouri
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The c-Jun NH2-terminal Kinase (JNK) pathway represents one sub-group of the mitogen-activated protein (MAP) kinases which plays an important role in various inflammatory diseases states, including inflammatory bowel disease (IBD). Significant progress towards understanding the function of the JNK signaling pathway has been achieved during the past few years. Blockade of the JNK pathway with JNK inhibitors in animal models of IBD lead to resolution of intestinal inflammation. Current data suggest specific JNK inhibitors hold promise as novel therapies in IBD.