Elsevier, Molecular Aspects of Medicine, 1(33), p. 63-76
DOI: 10.1016/j.mam.2011.11.001
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The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC), on which it also acts in a positive feedback loop to induce enzymes involved in its own synthesis. RA is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA-ASC). Moreover, RA modulates Foxp3+ TREG and Th17 differentiation. Thus, although recent evidence indicates that RA could be used as an effective “mucosal adjuvant” in vaccines, it also appears to be required for establishing intestinal immune tolerance. Here we discuss the roles proposed for RA in shaping intestinal immune responses and tolerance at the gut mucosal interface. We also focus on recent data exploring the mechanisms by which gut-associated DC acquire RA-producing capacity.