Published in
American Society of Hematology, Blood, 4(127), p. 436-448, 2016
DOI: 10.1182/blood-2015-05-646935
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Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia
Journal article published in 2015 by
Michaela Wagner,
Madlen Oelsner,
Andrew Moore,
Frederik Gotte,
Peer-Hendrik Kuhn 
,
Torsten Haferlach,
Michael Fiegl,
Christian Bogner,
E. Joanna Baxter,
Christian Peschel,
George A. Follows,
Ingo Ringshausen
,
Torsten Haferlach,
Michael Fiegl,
Christian Bogner,
E. Joanna Baxter,
Christian Peschel,
George A. Follows,
Ingo Ringshausen
This paper is made freely available by the publisher.
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Abstract
Key Points Activation of innate immune receptors induces an antiapoptotic signal and proliferation in ZAP-70–positive CLL dependent on Syk activation. TLR9 activation autonomously induces BCR signaling in ZAP-70–positive CLL based on an auto/paracrine feedback loop involving immunoglobulin M.