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American Society of Hematology, Blood, 4(127), p. 464-472, 2016

DOI: 10.1182/blood-2013-11-539262

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Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

Journal article published in 2015 by Valerie Tutwiler, Daria Madeeva, Hyun Sook Ahn, Izabella Andrianova, Vincent Hayes, X. Long Zheng, Douglas B. Cines ORCID, Steven E. McKenzie ORCID, Mortimer Poncz, Lubica Rauova ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key PointsThe procoagulant nature of HIT can be simulated in a microfluidic model using human blood and its components. PF4/glycosaminoglycans/immunoglobulin G complexes activate monocytes through FcγRIIA to generate TF and thrombin, leading to coated platelets in HIT.