Published in

Wiley, British Journal of Haematology, 6(160), p. 838-841, 2012

DOI: 10.1111/bjh.12132

Links

Tools

Export citation

Search in Google Scholar

Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study

Journal article published in 2012 by Tarec C. El-Galaly ORCID, Marianne T. Severinsen ORCID, Kim Overvad, Rudi Steffensen, Anders K. Vistisen, Anne Tjønneland, Søren R. Kristensen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.