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National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, 11(119), p. 1528-1533, 2011

DOI: 10.1289/ehp.1103423

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Global Methylation in Exposure Biology and Translational Medical Science

Journal article published in 2011 by Heather H. Nelson, Carmen J. Marsit ORCID, Karl T. Kelsey
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Many groups are actively investigating how the epigenetic state relates to environmental exposures and development of disease, including cancer. There are myriad choices for capturing and measuring the epigenetic state of a tissue, ranging from assessing the total methyl-CpG content to array-based platforms that simultaneously probe hundreds of thousands of CpG loci. There is an emerging literature that uses CpG methylation at repetitive sequences, including LINE-1 (long interspersed nuclear element-1) elements, to capture the epigenomic state.