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European Centre for Disease Prevention and Control, Eurosurveillance, 41(20), 2015

DOI: 10.2807/1560-7917.es.2015.20.41.30042

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Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection

Journal article published in 2015 by Sang Won Park ORCID, Ranawaka A. P. M. Perera, Pyoeng Gyun Choe, Eric H. Y. Lau, Seong Jin Choi, June Young Chun, Hs Oh, Hong Sang Oh, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim ORCID, Wan Beom Park, Nam Joong Kim, Leo Lit Man Poon ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Plaque reduction neutralisation tests (PRNT), microneutralisation (MN), Middle East respiratory syndrome (MERS)-spike pseudoparticle neutralisation (ppNT) and MERS S1-enzyme-linked immunosorbent assay (ELISA) antibody titres were compared using 95 sera from 17 patients with MERS, collected two to 46 days after symptom onset. Neutralisation tests correlated well with each other and moderately well with S1 ELISA. Moreover to compare antigenic similarity of genetically diverse MERS-CoV clades, the response of four sera from two patients sampled at two time periods during the course of illness were tested by 90% PRNT. Genetically diverse MERS-CoV clades were antigenically homogenous. ; published_or_final_version