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Nature Research, Scientific Reports, 1(3), 2013

DOI: 10.1038/srep01792

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Plasmon based biosensor for distinguishing different peptides mutation states

Journal article published in 2013 by Gobind Das, Manohar Chirumamilla ORCID, Andrea Toma, Anisha Gopalakrishnan, Remo Proietti Zaccaria, Alessandro Alabastri, Marco Leoncini, Enzo M. Di Fabrizio
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.