Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Yusuf, Osman; Wöhrl, Stefan; Who, Collaborating Ctr Asthma; Yz, Chen; Schunemann, Holger J.; Wj, Fokkens; Wk, Dolen; Ww, Busse; Woehrl, S.; Me, Zernotti; Anto, Jm M.; Schuenemann, H. J. and Togias A.; Hj, Zar; Van Wijk, Roy Gerth; Om, Yusuf; Carlsen, K. C. Lodrup; Van Weel, Chris; Weel, C. van; Wang, Dy; Rodriguez, Mr Roman; Papadopoulos, Ng G.; Schünemann, Hj; Popov, Ted; Casale, Tb B.; Rosado-Pinto, José; Rabe, Klaus; Cruz, Aa Alavaro; D., Bateman E; Bousquet, Philippe J.; Scadding, Glenis; Pj, Sterk; Rt, Stein; Simons, Frances Estelle Reed; S., Bonini; Schmid-Grendelmeier, Peter; Pd, Schmid Grendelmeier; Postma, Ds; Fe, Simons; Ang, Cs S.; Bousquet, Jean; Ta, Popov; L., Brozek J; van Wijk, Rg Gerth and Gimeno-Santos E.; Gk, Scadding; Baena-Cagnani, Ce E.; Bel, Eh H.; W., Canonica G; Jensen, Cb Bindslev; Demoly, Pascal; U., Darsow; Togias, Alkis; Kc, Lodrup Carlsen; Kf, Rabe; Kheder, Ali Ben; Kerkhof, Marjan van de; Martinez, Fernando; Akdis, Mübeccel; Larenas, Désirée; Bergmann, Kc C. and Berrissoul F.; Lodrup Carlsen, Karin C.; Auffray, Charles; Bachert, Claus; Gs, Ouedraogo; Mp, Orru; Bieber, Thomas; Samolinski, B. and Agache I.; Who, Collaborating Center for Asthma and Rhinitis; Chen, Yz Z.; Nyembue, Tshipukane; Re, O'Hehir; Chiriac, Am M.; Bleecker, Er R.; Price, David and Rabe K. F.; Td, Nyembue; Boner, Al L.; Andrianarisoa, A.; Annesi-Maesano, I.; Mc, Nawijn; Kaliner, Michael A.; Ballester, F.; Keil, Thomas; Bennoor, Kazi Saifuddin; Basagaña, X.; Carlsen, Kai-Håkon; Bedbrook, A.; O'Hehir, Robyn; Boulet, Lp P.; Beghé, B.; Beji, M.; Ben Kheder, Ali; Maurer, Marcus; Benet, M.; Ma, Kaliner; Carr, Warner; Cesario, Alfredo; N'Goran, Bk Koffi; Ohta, K. and Papadopoulos N. G.; Agache, I.; Brightling, Ce E.; Eo, Meltzer; Cox, Latonia; Koppelman, Gerard H.; Jacquemin, Bénédicte; Dolen, Wk K.; Gd, Marshall; Mj, Makela; Just, Jocelyne and Kalayci O.; Custovic, Adnan; Kowalski, Marek L.; Ja, Fonseca; Kalayci, Omer; Pison, Christophe; van Weel, C.; Kauffmann, Francine; Bateman, Ed D.; Dahl, Ronald; Kerkhof, Marjan and Khayat G.; Rabe, Kf F.; Palkonen, Susanna; Wöhrl, Stefan; Panzner, Petr; Wickman, Magnus; Busse, Ww W.; Lt, Le; Wright, J.; Williams, Dennis; Pawankar, Ruby; Khayat, G.; Carlsen, Kh H.; Passalacqua, G.; Ring, Johannes; Didi, Toufik; Yorgancioglu, Arzu; Pigearias, Bernard; Kogevinas, M.; Roman Rodriguez, M.; Camargos, Pa A. M.; Pin, Isabelle; Rosado-Pinto, José; Lavi, I.; Yusuf, Om M.; Pinart, M.; Le, Lan Thi Tuyet; Toskala, Elina; Kull, Inger; Bush, Andrew; Zidarn, Mihaela; Koffi N'Goran, Bernard; Zar, Hj J.; Douagui, Habib; Zuberbier, Torsten; Zhong, N.; Kuna, Piotr; Zernotti, Me E.; Stein, Renato T.; Dubakiene, Ruta and El-Meziane A.; Larenas, Désirée; Ml, Kowalski; Porta, Daniela; Postma, Dirkje S.; Wang, De Yun; Fokkens, Wj J.; Schmid-Grendelmeier, Pd D.; Costa, David J.; Berrissoul, Fouad; Fonseca, Ja A.; Gh, Koppelman; Lieberman, Phil; Fthenou, E. and Gamkrelidze A.; Lipworth, Brian; Ratomaharo, Julia; Mahboub, Bassam and Makela M. J.; Garcia-Aymerich, J.; Guerra, Stefano; Darsow, Ulf; Rezagui, Djamel; Pj, Bousquet; Martin, Francis; Popov, Ta A.; Haddad, H. and Hellings P. W.; Roberts, R.; Hohmann, C.; Reitamo, Sakari; Tremblay, Yves; Roca, Joseph; Hellquist-Dahl, B.; Jm, Anto; Rogala, B.; Haahtela, Tari; Brozek, Jan L.; Howarth, Peter; Canonica, Giorgio Walter; El-Meziane, Abdellah; Romano, Antonino and Rosado-Pinto J.; Valenta, Rudolf; Melen, Erik; Humbert, Marc; Gamkrelidze, Amiran; Ryan, Dermot; Valeyre, Dominique; Sanchez-Borges, Mario; Mazon, A.; Mihaltan, F. and Mohammad Y.; Vandenplas, Olivier; Gimeno-Santos, E.; Mohammad, Yousser; Momas, Isabelle; Sheikh, Aziz; Marshall, Gailen D. and Mazon A.; Vassilaki, M.; Jo, Hourihane; Morais-Almeida, Mario and Mullol J.; Siroux, Valérie and Schmid-Grendelmeier P. D.; Varraso, R.; Viegi, Giovanni and Wang D. Y.; Ha, Smit; Muraro, Antonella; Sooronbaev, Talant; Hourihane, Jo O.; Meltzer, Eli O.; Naclerio, Robert; Mullol, Joaquim; Nafti, Salim and Namazova-Baranova L.; Terreehorst, Ingrid; Oddie, Sam; Sunyer, J.; Makela, Mj J.; Okamoto, Yoshitaka; Namazova-Baranova, Leyla; Hellings, Peter W.; Martinez, Fd D.; Ozdemir, Cevdet and Ouedraogo G. S.; Pw, Hellings; Mohammadi, Azzeddine; Nawijn, Martijn C.; Nyembue, Td D.; Scadding, Gk K.; O'Hehir, Re E.; Orru, M. P.; Kh, Carlsen; Dj, Costa; Simons, Fe E. R.; Ouedraogo, Gs S.; Am, Chiriac; Gw, Canonica; Tb, Casale; Smit, Ha A.; Pa, Camargos; Gerth Van Wijk, Roy; Sterk, Pj J.; Aa, Cruz; Jl, Brozek; Ce, Brightling; Lp, Boulet; Er, Bleecker; Koffi N'goran, B.; Kc, Bergmann; Price, David; Bindslev Jensen, Carsten; Ks, Bennoor; Mauerer, M.; C., Pison; Eh, Bel; Ed, Bateman; J., Ring; Ce, Baena Cagnani; Al, Boner; Cs, Ang; T., Stein R; E., Toskala; Anto, Josep; Ng, Papadopoulos; Bousquet, Philippe Jean; Casale, Thomas; Cruz, Alavaro; Bleecker, Eugene; Brightling, Christopher; Camargos, Paulo Augusto Moreira; Fonseca, Joao; Basagaña, X.; Beghé, B.; Mäkelä, Mika J.; Fatima Mazon, A. di; Gerth van Wijk, R.; Collaborating Center for Asthma and Rhinitis, W. H. O.; In collaboration with the Who Collaborating Center for Asthma and Rhinitis, Boner A. L.

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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Journal article published in 2012 by Osman Yusuf, Stefan Wöhrl, Collaborating Ctr Asthma Who, Chen Yz, Holger J. Schunemann, Fokkens Wj, Dolen Wk, Busse Ww, S. Woehrl, Zernotti Me, Jm M. Anto, H. J. and Togias A. Schuenemann, Zar Hj, Roy Gerth Van Wijk, Yusuf Om and other authors.

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Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel

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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Abstract