Published in
American Society of Hematology, Blood, 15(127), p. 1930-1939, 2016
DOI: 10.1182/blood-2015-09-672428
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- ORCID
- American Society of Hematology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
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Caveolin-1 regulates TCR signal strength and regulatory T cell differentiation into alloreactive T cells
Journal article published in 2016 by
Anne Schonle,
Miguel Angel del Pozo 
,
Frederike A. Hartl,
Jan Mentzel,
Theresa Noltner,
Katharina S. Rauch,
Alessandro Prestipino,
Sebastian A. Wohlfeil,
Petya Apostolova,
Anne-Kathrin Hechinger,
Wolfgang Melchinger,
Kerstin Fehrenbach,
Marta C. Guadamillas,
Marie Follo,
Gabriele Prinz
and other authors.
,
Frederike A. Hartl,
Jan Mentzel,
Theresa Noltner,
Katharina S. Rauch,
Alessandro Prestipino,
Sebastian A. Wohlfeil,
Petya Apostolova,
Anne-Kathrin Hechinger,
Wolfgang Melchinger,
Kerstin Fehrenbach,
Marta C. Guadamillas,
Marie Follo,
Gabriele Prinz
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Cav-1–deficient T cells preferentially differentiate into Tregs, which translates into lower GVHD severity in mice. Reduced TCR:Lck clustering in Cav-1–deficient T cells is responsible for reduced TCR downstream signaling events promoting Treg differentiation.