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Elsevier, Parkinsonism & Related Disorders, 7(14), p. 539-543

DOI: 10.1016/j.parkreldis.2008.08.003

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Genetic variation of Omi/HtrA2 and Parkinson’s disease

Journal article published in 2008 by Owen A. Ross, Alexandra I. Soto, Carles Vilariño-Güell ORCID, Michael G. Heckman, Nancy N. Diehl, Mary M. Hulihan, Jan O. Aasly, Sigrid Sando, J. Mark Gibson, J. Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski and other authors.
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This paper is available in a repository.

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Abstract

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson’s disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson’s disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson’s disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson’s disease.