Seven newly identified loci for autoimmune thyroid disease

Warren-Perry, M.; Watkins, N. A.; Webster, J.; Weedon, M. N.; Wilson, A. G.; Woodburn, M.; Yau, C.; Young, A. H.; Zeggini, E.; Worthington, J.; Jd, Cooper; Mj, Simmonds; Nm, Walker; Nicol Ferrier, I.; Gwilliam, R.; Hall, A.; Hammond, N.; Hardy, M.; Harrison, P.; Hassanali, N.; Hebaishi, H.; Hines, S.; Hinks, A.; Hitman, G. A.; Oj, Brand; Hocking, L.; Holmes, C.; Simmonds, Matthew J.; Howard, E.; Howard, P.; Howson, J. M. M.; Hughes, D.; Hunt, S.; Isaacs,; Jain, M.; Jewell, D. P.; Johnson, T.; Jolley,; Jones, I. R.; Jones, L. A.; Kirov, G.; Walker, Neil M.; Langford, C. F.; Lango-Allen, H.; Mark Lathrop, G.; Lee, J.; Cooper, Jason D.; Lee, K. L.; Lees, C.; Lewis, K.; Lindgren, C. M.; Maisuria-Armer, M.; Maller, J.; Mansfield, J.; Marchini, J. L.; Martin, P.; Massey, D. C. O.; McArdle, W. L.; McGuffin, P.; McLay, K. E.; McVean, G.; Mentzer, A.; Mimmack, M. L.; Morgan, A. E.; Morris, A. P.; Mowat, C.; Munroe, P. B.; Myers, S.; Newman, W.; Nimmo, E. R.; O’Donovan, M. C.; Onipinla, A.; Ovington, N. R.; Owen, M. J.; Palin, K.; Palotie, A.; Parnell, K.; Pearson, R.; Stevens, Helen; Pernet, D.; Perry, J. R. B.; Phillips, A.; Plagnol,; Prescott, N. J.; Prokopenko, I.; Quail,; Rafelt, S.; Rayner, N. W.; Reid, D. M.; Renwick, A.; Ring, S. M.; Robertson, N.; Robson, S.; Russell, E.; St Clair, D.; Sambrook, J. G.; Sanderson,; Sawcer, S. J.; Schuilenburg, H.; Scott, C. E.; Burren, Oliver; Scott, R.; Seal, S.; Shaw-Hawkins, S.; Shields, B. M.; Smyth, D. J.; Wallace, Chris; Somaskantharajah, E.; Spanova, K.; Steer, S.; Stephens, J.; Stirrups, K.; Brand, Oliver J.; Stone,; Strachan, D. P.; Su, Z.; Stevens, Helen E.; Symmons, D. P. M.; Thompson,; Thomson, W.; Tobin,; Travers, M. E.; Turnbull, C.; Vukcevic, D.; Ja, Franklyn; Wain, L.; Paul Wordsworth, B.; Hall, A. S.; Ja, Todd; Hattersley, A. T.; Hill, A. V. S.; Mathew, C. G.; Pembrey, M.; Guo, Hui; Satsangi, J.; Stratton, M. R.; Hurles, M. E.; Ouwehand, W. H.; Parkes, M.; Rahman, N.; Samani, N. J.; Kwiatkowski, D. P.; McCarthy, M. I.; Sc, Gough; Aerts, J.; Ahmad, T.; Arbury, H.; Attwood, A.; Auton, A.; Ball, S. G.; Balmforth, A. J.; Barnes, C.; Barrett, J. C.; Barroso, I.; Barton, A.; Bennett, A. J.; Bhaskar, S.; Blaszczyk, K.; Todd, John A.; Bowes, J.; Braund, P. S.; Bredin, F.; Breen, G.; Brown, M. J.; Bruce, I. N.; Bull, J.; Burton, J.; Byrnes, J.; Caesar, S.; Cardin, N.; Clee, C. M.; Coffey, A. J.; Connell, J. M. C.; Coleman, Gillian; Conrad, D. F.; Dominiczak, A. F.; Downes, K.; Drummond, H. E.; Dudakia, D.; Dunham, A.; Ebbs, B.; Eccles, D.; Edkins, S.; Edwards, C.; Elliot, A.; Emery, P.; Franklyn, Jayne A.; Evans, D. M.; Evans, G.; Eyre, S.; Farmer, A.; Flynn, E.; Forbes, A.; Forty, L.; Frayling, T. M.; Freathy, R. M.; Giannoulatou, E.; Gibbs, P.; Gilbert, P.; Gordon-Smith, K.; Gray, E.; Green, E.; Groves, C. J.; Grozeva, D.; Consortium, Wellcome Trust Case Control; Brown,; Burton, P. R.; Caulfield, M. J.; Compston, A.; Farrall, M.; Duncanson, A.; Gough, Stephen C. L.; Craddock, N.; Deloukas, P.; Cooper, Simmonds MJ Walker NM Burren OS Brand OJ Guo H Wallace C Stevens H Coleman G WTCCC Franklyn JA Todd JA Gough Sc; Donnelly, P.

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Seven newly identified loci for autoimmune thyroid disease

Journal article published in 2012 by M. Warren-Perry, N. A. Watkins, J. Webster, M. N. Weedon, A. G. Wilson, M. Woodburn, C. Yau, A. H. Young, E. Zeggini, J. Worthington, Cooper Jd, Simmonds Mj, Walker Nm, I. Nicol Ferrier, R. Gwilliam and other authors.

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Abstract

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

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Seven newly identified loci for autoimmune thyroid disease

Abstract