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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (8), p. 1637-1643, 2012

DOI: 10.3762/bjoc.8.187

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Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

Journal article published in 2012 by Anthony R. Martin, Anthony Chartoire, Alexandra M. Z. Slawin ORCID, Steven P. Nolan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium.