Published in
Elsevier, European Urology, 4(62), p. 677-684
DOI: 10.1016/j.eururo.2012.02.018
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Stage-Specific Impact of Tumor Location on Oncologic Outcomes in Patients With Upper and Lower Tract Urothelial Carcinoma Following Radical Surgery
,
David A. Green,
Pierre I. Karakiewicz,
Marko Babjuk,
Vitaly Margulis,
Robert S. Svatek,
Jay D. Raman ,
Ehdaie B Cha EK Green DA Karakiewicz PI Babjuk M Margulis V Raman JD Svatek RS Fajkovic H Lee RK Novara G Hansen J Daneshmand S Lotan Y Kassouf W Fritsche HM Pycha A Fisch M Scherr DS Shariat Sf Rink M.,
Harun Fajkovic,
Richard K. Lee,
Giacomo Novara,
Jens Hansen,
Siamak Daneshmand
and other authors.
Full text: Unavailable
Abstract
Background: Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). Objective: The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. Design, setting, and participants: Data were collected from 4335 patients with UCB treated with radical cystectomy (RC) and bilateral pelvic lymphadenectomy (PLND), 877 patients with ureteral UTUC, and 1615 with pelvicalyceal UTUC treated with radical nephroureterectomy (RNU). No patient received preoperative chemotherapy or radiation therapy. Interventions: Patients were treated with RC and bilateral PLND or RNU. Measurements: Outcomes were assessed according to primary tumor location. Results and limitations: Compared to UTUC patients, UCB patients had more advanced tumor stage and higher grade, and they were more likely to harbor lymphovascular invasion (LVI) and lymph node metastasis (p 0.05). In pT2 and pT3 tumors, there was no difference in outcomes between the three tumor locations. In pT4 tumors, patients with ureteral and pelvicalyceal tumors were more likely to experience disease recurrence and mortality compared to UCB patients (p